MovDisordV3, France, Analysis, bibRecord, 000310

Cortical Excitability in DYT-11 Positive Myoclonus Dystonia

Identifieur interne : 000310 ( France/Analysis ); précédent : 000309; suivant : 000311

Cortical Excitability in DYT-11 Positive Myoclonus Dystonia

Auteurs : Sabine Meunier [France] ; George Lourenco [France] ; Emmanuel Roze [France] ; Emmanuelle Apartis [France] ; Jean-Marc Trocello [France] ; Marie Vidailhet [France]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0247751

Descripteurs français

Pascal (Inist)
- Myoclonie, Dystonie, Pathologie du système nerveux, Excitabilité, Stimulation magnétique transcrânienne, Physiopathologie.

English descriptors

KwdEn :
- Dystonia, Excitability, Myoclonus, Nervous system diseases, Pathophysiology, Transcranial magnetic stimulation.

Abstract

Myoclonus-dystonia (M-D) is an autosomal dominant movement disorder caused by mutations in the ε-sarcoglycan gene (DYT11). We explore pathophysiological characteristics of M-D with the hypothesis that they may be different from those of sporadic or genetic dystonia. We compared five carriers of the DYT11 gene mutation and 10 healthy controls. Using transcranial magnetic stimulation, we measured parameters assessing cortical membrane excitability (active motor threshold, aMT) and synaptic activity (short interval, sICI) and afferent (AI) intracortical inhibitions and their interaction. aMT was significantly higher in the DYT11 gene carriers than in normal subjects. The others parameters (sICI, AI and their interaction) were not different between the two groups. In DYT11 gene carriers cortical membrane excitability was impaired while parameters assessing cortical synaptic activity were normal. Opposite results have been obtained in focal sporadic and generalized DYT1 dystonias.

Affiliations:

France
Paris

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001279
to stream PascalFrancis, to step Curation: 001A40
to stream PascalFrancis, to step Checkpoint: 001309
to stream Main, to step Merge: 003917
to stream Main, to step Curation: 002A78
to stream Main, to step Exploration: 002A78
to stream France, to step Extraction: 000310

Links to Exploration step

Pascal:08-0247751

Le document en format XML

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<term>Pathophysiology</term>
<term>Transcranial magnetic stimulation</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Myoclonie</term>
<term>Dystonie</term>
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<term>Excitabilité</term>
<term>Stimulation magnétique transcrânienne</term>
<term>Physiopathologie</term>
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<front><div type="abstract" xml:lang="en">Myoclonus-dystonia (M-D) is an autosomal dominant movement disorder caused by mutations in the ε-sarcoglycan gene (DYT11). We explore pathophysiological characteristics of M-D with the hypothesis that they may be different from those of sporadic or genetic dystonia. We compared five carriers of the DYT11 gene mutation and 10 healthy controls. Using transcranial magnetic stimulation, we measured parameters assessing cortical membrane excitability (active motor threshold, aMT) and synaptic activity (short interval, sICI) and afferent (AI) intracortical inhibitions and their interaction. aMT was significantly higher in the DYT11 gene carriers than in normal subjects. The others parameters (sICI, AI and their interaction) were not different between the two groups. In DYT11 gene carriers cortical membrane excitability was impaired while parameters assessing cortical synaptic activity were normal. Opposite results have been obtained in focal sporadic and generalized DYT1 dystonias.</div>
</front>
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<name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name>
<name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name>
<name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name>
<name sortKey="Lourenco, George" sort="Lourenco, George" uniqKey="Lourenco G" first="George" last="Lourenco">George Lourenco</name>
<name sortKey="Lourenco, George" sort="Lourenco, George" uniqKey="Lourenco G" first="George" last="Lourenco">George Lourenco</name>
<name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name>
<name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
<name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
<name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
<name sortKey="Trocello, Jean Marc" sort="Trocello, Jean Marc" uniqKey="Trocello J" first="Jean-Marc" last="Trocello">Jean-Marc Trocello</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Cortical Excitability in DYT-11 Positive Myoclonus Dystonia

Cortical Excitability in DYT-11 Positive Myoclonus Dystonia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri